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FLASH GENE
Symbol DEDD contributors: mct - updated : 13-10-2010
HGNC name death effector domain containing
HGNC id 2755
Location 1q23.3      Physical location : 161.090.770 - 161.102.478
Synonym name death effector domain-containing testicular molecule
Synonym symbol(s) DEFT, KE05, FLDED1, CASP8IP1, DEDD1, DEDpro1
DNA
TYPE functioning gene
STRUCTURE 11.71 kb     6 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2362 - 318 - -
5 - 2329 - 318 - -
6 - 2300 - 318 - -
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal death effector domain DED
  • two nuclear localization signals (NLS)
  • C terminus with some homology with histones
  • mono polymer homomer , heteromer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • important mediator for death receptors and targeting caspases to the nucleus
  • acting as a novel inhibitor of the mitotic Cdk1/cyclin B1 complex
  • regulates degradation of intermediate filaments during apoptosis
  • may harbor important roles in glucose homeostasis and its deficiency might be involved in the pathogenesis of type 2 diabetes mellitus
  • possible involvement of DEDD in glucose homeostasis
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text CD95 induced apoptosis
    PATHWAY
    metabolism
    signaling
    a component
  • homodimerizing and heterodimerizing with DEDD2 binding tandem DED containing caspases CASP8, CASP10
  • forms a complex with AKT1 and Hsp90
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inhibits cyclin-dependent kinase-1 (CDK1) function, thereby preventing CDK1-dependent inhibitory phosphorylation of S6 kinase-1 (RPS6KB1)
  • physically interacts with SMAD3 (through its interaction with SMAD3, DEDD is a novel negative regulator of the TGF-B1 signaling pathway)
  • interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target may be a candidate target for cancer therapy
    ANIMAL & CELL MODELS