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FLASH GENE
Symbol SGCG contributors: mct - updated : 14-12-2021
HGNC name sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
HGNC id 10809
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • the cytoplasmic and extracellular domains each contain 1 phosphorylation site
  • an extracellular C terminus
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Sgcg
    homolog to rattus Rn.7061
    homolog to Drosophila Scg&dgr;
    homolog to C.elegans sgn-1
    Homologene
    FAMILY
  • sarcoglycan beta/delta/gamma family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • sarcolemma
  • type II membrane protein
    • basic FUNCTION
  • providing a link between the membrane associated cytoskeleton and the extracellular matrix
  • stabilizing the link between dystroglycan and dystrophin/utrophin
  • integral membrane protein responsible for maintaining the integrity of the muscle cell sarcolemma
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text muscle development
    PATHWAY
    metabolism
    signaling
    a component
  • associating with other sarcoglycans and sarcospan in a stochiometrically equal complex
  • component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the f-actin cytoskeleton and the extracellular matrix
  • vital component of the Dystrophin Complex, which together facilitate normal muscle function
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to dystrophin and SNTA1
  • SGCG is expressed in the cerebrovascular system and is specifically regulated by astroglial GJB6 channels
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LGMD2C
    related resource Sarcoglycan database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS