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FLASH GENE
Symbol SGCG contributors: mct - updated : 14-12-2021
HGNC name sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
HGNC id 10809
Corresponding disease
LGMD2C limb girdle muscular dystrophy 2C
Location 13q12.12      Physical location : 23.755.059 - 23.899.304
Synonym name
  • 35 kDa dystrophin-associated glycoprotein
  • Maghrebian myopathy (autosomal recessive)
  • gamma sarcoglycan
  • Synonym symbol(s) 35DAG, DAGA4, LGMD2C, DAPA4, DAPA4G,A4, MAM, DMDA, SCG3, TYPE, DMDA1, SCARMD2, MGC130048
    DNA
    TYPE functioning gene
    STRUCTURE 164.65 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1696 32.2 291 - 2020 31682967
    9 - 1745 32.2 291 - 2020 31682967
    8 - 1594 32.2 291 - 2020 31682967
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel     Homo sapiens
    Nervousbrain     Homo sapiens
    Reproductivefemale systembreastmammary gland  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothvessel   Homo sapiens
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the cytoplasmic and extracellular domains each contain 1 phosphorylation site
  • an extracellular C terminus
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Sgcg
    homolog to rattus Rn.7061
    homolog to Drosophila Scg&dgr;
    homolog to C.elegans sgn-1
    Homologene
    FAMILY
  • sarcoglycan beta/delta/gamma family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • sarcolemma
  • type II membrane protein
  • basic FUNCTION
  • providing a link between the membrane associated cytoskeleton and the extracellular matrix
  • stabilizing the link between dystroglycan and dystrophin/utrophin
  • integral membrane protein responsible for maintaining the integrity of the muscle cell sarcolemma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text muscle development
    PATHWAY
    metabolism
    signaling
    a component
  • associating with other sarcoglycans and sarcospan in a stochiometrically equal complex
  • component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the f-actin cytoskeleton and the extracellular matrix
  • vital component of the Dystrophin Complex, which together facilitate normal muscle function
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to dystrophin and SNTA1
  • SGCG is expressed in the cerebrovascular system and is specifically regulated by astroglial GJB6 channels
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LGMD2C
    related resource Sarcoglycan database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS