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FLASH GENE
Symbol SGCG contributors: npt/ - updated : 20-05-2006
HGNC name sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
HGNC id 10809
Corresponding disease
LGMD2C limb girdle muscular dystrophy 2C
Location 13q12.12      Physical location : 23.755.059 - 23.899.304
Synonym name
  • 35 kDa dystrophin-associated glycoprotein
  • Maghrebian myopathy (autosomal recessive)
  • gamma sarcoglycan
  • Synonym symbol(s) 35DAG, DAGA4, LGMD2C, DAPA4, DAPA4G,A4, MAM, DMDA, SCG3, TYPE, DMDA1, SCARMD2, MGC130048
    DNA
    TYPE functioning gene
    STRUCTURE 144.21 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC387903 13 LOC387903 ESTRRA 13q12.11 estrogen-related receptor alpha pseudogene LOC387904 13 similar to hypothetical protein GPRK6P 13pter-q21 G protein-coupled receptor kinase 6 pseudogene LOC387905 13 LOC387905 FLJ25952 13q12.11 hypothetical protein FLJ25952 LOC387906 13 similar to RIKEN cDNA 5033406L14 LOC390382 13 similar to histone 1, H2bc; H2B histone family, member S FLJ34588 13q12.11 Smhs2 homolog (rat) LOC387907 13 similar to bA271B5.1 (similar to ribosomal protein S7) FGF9 13q11-q12 fibroblast growth factor 9 (glia-activating factor) LOC387908 13 similar to Ferritin heavy chain (Ferritin H subunit) LOC390383 13 similar to inositol polyphosphate multikinase LOC387909 13 hypothetical gene supported by AK130366 LOC283530 13q12.12 hypothetical LOC283530 LOC387910 13 LOC387910 SGCG 13q12 sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) SACS 13q12 spastic ataxia of Charlevoix-Saguenay (sacsin) TNFRSF19 13q12.11-q12.3 tumor necrosis factor receptor superfamily, member 19 MIPEP 13q12 mitochondrial intermediate peptidase LOC387911 13 similar to hypothetical protein MGC48915 LOC390384 13 similar to hypothetical protein DKFZp434A171 SPATA13 13q12.13 spermatogenesis associated 13 MGC48915 13q12.13 hypothetical protein MGC48915 LOC390385 13 similar to hypothetical protein, MGC:7199 HCP33 13q12.13 cytochrome c, somatic pseudogene ADPRTL1 13q11 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1 LOC387912 13 similar to TPTE and PTEN homologous inositol lipid phosphatase ATP12A 13q12.1-q12.3 ATPase, H+/K+ transporting, nongastric, alpha polypeptide LOC390386 13 similar to hypothetical protein DKFZp434A171 RNF17 13q12 ring finger protein 17 TDRD4 13q12.12 tudor domain containing 4 CENPJ 13q12.13 centromere protein J LOC387913 13 similar to TPTE and PTEN homologous inositol lipid phosphatase LOC390387 13 similar to Striatin
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1661 32.2 291 - Noguchi (1995)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Reproductivefemale systembreastmammary gland  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the cytoplasmic and extracellular domains each contain 1 phosphorylation site
  • an extracellular C terminus
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Sgcg
    homolog to rattus Rn.7061
    homolog to Drosophila Scg&dgr;
    homolog to C.elegans sgn-1
    Homologene
    FAMILY
  • sarcoglycan beta/delta/gamma family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • sarcolemma
  • type II membrane protein
  • basic FUNCTION
  • providing a link between the membrane associated cytoskeleton and the extracellular matrix
  • stabilizing the link between dystroglycan and dystrophin/utrophin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text muscle development
    PATHWAY
    metabolism
    signaling
    a component
  • associating with other sarcoglycans and sarcospan in a stochiometrically equal complex
  • component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the f-actin cytoskeleton and the extracellular matrix
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to dystrophin and SNTA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LGMD2C
    related resource Sarcoglycan database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS