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FLASH GENE
Symbol CTDP1 contributors: - updated : 04-05-2007
HGNC name CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
HGNC id 2498
Corresponding disease
CCFDN congenital cataract, facial dysmorphism neuropathy syndrome
Location 18q23      Physical location : 77.439.800 - 77.514.507
Synonym name
  • TFIIF-associating CTD phosphatase 1
  • CTD of POLR2A, phosphatase of, subunit 1
  • RNA polymerase II subunit A C-terminal domain phosphatase
  • transcription factor IIF-associating CTD phosphatase 1
  • Synonym symbol(s) FCP1
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 74.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ZNF236 18q22-q23 zinc finger protein 236 MBP 18q23 myelin basic protein LOC388483 18 LOC388483 GALR1 18q23 galanin receptor 1 LOC390864 18 similar to amino acid feature: Rod protein domain, aa 266 .. 468; amino acid feature: globular protein domain, aa 32 .. 265 LOC125595 18q23 hypothetical LOC125595 LOC390865 18 similar to hypothetical protein LOC390866 18 LOC390866 LOC390867 18 similar to Splicing factor 3A subunit 2 (Spliceosome associated protein 62) (SAP 62) (SF3a66) LOC390868 18 similar to hypothetical protein LOC388484 18 LOC388484 SALL3 18q23 sal-like 3 (Drosophila) ATP9B 18q23 ATPase, Class II, type 9B NFATC1 18q23 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 LOC388485 18 LOC388485 LOC390869 18 similar to immediate early protein homolog LOC147294 18q23 similar to immediate early protein homolog FLJ25715 18q23 hypothetical protein FLJ25715 CTDP1 18q23 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 LOC390870 18 LOC390870 KCNG2 18q22-q23 potassium voltage-gated channel, subfamily G, member 2 FLJ22378 DIM1 FLJ21172 18q23 hypothetical protein FLJ21172 KIAA0863 18q23 KIAA0863 protein PARD6G 18q23 par-6 partitioning defective 6 homolog gamma (C. elegans)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3775 104.3 961 - Mandal
    - - 3612 93.4 867 - Mandal
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Endocrinepancreas    
    Lymphoid/Immunespleen    
    Visualeyeanterior segment   
     eyelens   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelial    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text posterior rhombomere
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C terminal domain phosphatase
  • one BRCT domain
  • one FCP1 homology domain
  • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Ctdp1
    homolog to dog LOC476158
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • an essential component of the eukaryotic transcription machinery
  • stimulating transcript elongation by RNAP II
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • may be a component of a RNA polymerase II holoenzyme complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein GTF2F1 (when phosphorylated)
    cell & other
    REGULATION
    activated by GTF2F1
    Other regulated by phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s) CCFDN
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS