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FLASH GENE
Symbol CRYL1 contributors: - updated : 06-01-2006
HGNC name crystallin, lambda 1
HGNC id 18246
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Skin/Tegumentskin    
Urinarykidney    
Visualeyelens   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a putative NAD/FAD binding domain (HCDH domain)
HOMOLOGY
interspecies ortholog to murine Cryl1
homolog to rattus cryl1
homolog to chimpanzee LOC452458
Homologene
FAMILY the 3-hydroxyacyl-CoA dehydrogenase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • maybe of similar function than 3-hydroxyacyl-CoA dehydrogenase
  • contributing to the refractive index and transparency of lens
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS