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FLASH GENE
Symbol MVP contributors: mct - updated : 23-10-2018
HGNC name major vault protein
HGNC id 7531
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to C.elegans f25b5.4
homolog to rattus Mvp
Homologene
FAMILY vault family of protein
CATEGORY structural protein , RNA associated , transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,vault
intracellular,nuclear envelope,pore
basic FUNCTION
  • cytoplasmic ribonucleoprotein complexes
  • secretory and excretory functions, mediating drug resistance via the nucleocytoplasmic transport
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text nucleocytoplasmic transport
    PATHWAY
    metabolism drug
    signaling
    a component constituent of vault: multisubunit structure,involved in nucleocytoplasmic transport
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • putative PTPN11 substrate ( regulation of MVP tyrosyl phosphorylation may play an important role in cell survival signaling)
  • cooperating with Ras for optimal EGF-induced Elk-1 activation and required for cell survival
  • KPNA7 interaction was confirmed for MVP and ZNF414, with distinct roles as novel regulators of pancreatic cancer cell growth
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in acute myeloid leukemia resistant to chemotherapy
    tumoral     --over  
    in multidrug-resistant cancer cells (AML)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS