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FLASH GENE

Symbol

MVP

contributors: mct - updated : 23-10-2018

HGNC name	major vault protein
HGNC id	7531

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p11.2      Physical location : 29.831.786 - 29.859.342
Synonym name	lung resistance related protein (LRP)
Synonym symbol(s)	LRP, VAULT1

DNA

TYPE	functioning gene
STRUCTURE	27.00 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (CAAT box)
	Binding site
text structure	Sp1 binding site located near to p53 binding motif

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed MVPV 1 - splicing 2850 - 896 - Scheffer MVPV 2 - splicing 2810 - 896 - Scheffer

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     highly Endocrine adrenal gland       highly Lymphoid/Immune spleen       highly   thymus       highly

cells

System Cell Pubmed Species Stage Rna symbol skin tegument secretory cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to C.elegans f25b5.4
	homolog to rattus Mvp

Homologene

FAMILY

vault family of protein

CATEGORY

structural protein , RNA associated , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,vault
	intracellular,nuclear envelope,pore

basic FUNCTION	cytoplasmic ribonucleoprotein complexes
	secretory and excretory functions, mediating drug resistance via the nucleocytoplasmic transport

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	nucleocytoplasmic transport

PATHWAY

metabolism

drug

signaling

a component

constituent of vault: multisubunit structure,involved in nucleocytoplasmic transport

INTERACTION

DNA

RNA

small molecule

protein	putative PTPN11 substrate ( regulation of MVP tyrosyl phosphorylation may play an important role in cell survival signaling)
	cooperating with Ras for optimal EGF-induced Elk-1 activation and required for cell survival
	KPNA7 interaction was confirmed for MVP and ZNF414, with distinct roles as novel regulators of pancreatic cancer cell growth

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in acute myeloid leukemia resistant to chemotherapy tumoral     --over   in multidrug-resistant cancer cells (AML)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS