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FLASH GENE
Symbol MVP contributors: mct - updated : 23-10-2018
HGNC name major vault protein
HGNC id 7531
Location 16p11.2      Physical location : 29.831.786 - 29.859.342
Synonym name lung resistance related protein (LRP)
Synonym symbol(s) LRP, VAULT1
DNA
TYPE functioning gene
STRUCTURE 27.00 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box)
Binding site
text structure Sp1 binding site located near to p53 binding motif
MAPPING cloned Y linked   status provisional
Physical map
LOC388241 16 similar to PI-3-kinase-related kinase SMG-1 isoform 2; lambda/iota protein kinase C-interacting protein; phosphatidylinositol 3-kinase-related protein kinase MGC5178 16p12.1 hypothetical protein MGC5178 LOC388242 16 similar to hypothetical protein BC011981 KIAA0220 16p12.1 KIAA0220 protein LAT1-3TM 16p12 LAT1-3TM protein LOC388243 16 similar to carbonic anhydrase VA, mitochondrial precursor; carbonic anhydrase V, mitochondrial; carbonic dehydratase SPN 16p11.2 sialophorin (gpL115, leukosialin, CD43) QPRT 16q13 quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating)) FLJ35681 16p12.1 hypothetical protein FLJ35681 ZG16 16p12.1 zymogen granule protein 16 KIF22 16p11.2 kinesin family member 22 MAZ 16p11.2 MYC-associated zinc finger protein (purine-binding transcription factor) LOC112476 16p12.1 similar to lymphocyte antigen 6 complex, locus G5B; G5b protein; open reading frame 31 MGC4606 16p12.1 hypothetical protein MGC4606 MVP 16p11.2 major vault protein CDIPT 16p12.1 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) PSK-1 16p12.1 type I transmembrane receptor (seizure-related protein) KCTD13 16p11.2 potassium channel tetramerisation domain containing 13 LOC253982 16p12.1 hypothetical protein LOC253982 LOC124446 16p12.1 hypothetical protein BC017488 PSK 16p12.1 hypothetical protein BC017488 TAO1 16p11.2 hypothetical protein BC017488 HIRIP3 16q13 HIRA interacting protein 3 FLJ90652 16p12.1 hypothetical protein FLJ90652 DOC2A 16q13 double C2-like domains, alpha DKFZP434I2117 16p12.1 hypothetical protein DKFZp434I2117 ALDOA 16q22.2 aldolase A, fructose-bisphosphate PPP4C 16p12-p11 protein phosphatase 4 (formerly X), catalytic subunit TBX6 16p11.2 T-box 6 MGC10500 16p12.1 hypothetical protein MGC10500
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2850 - 896 - Scheffer
- splicing 2810 - 896 - Scheffer
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Endocrineadrenal gland   highly
Lymphoid/Immunespleen   highly
 thymus   highly
cells
SystemCellPubmedSpeciesStageRna symbol
skin tegumentsecretory cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to C.elegans f25b5.4
homolog to rattus Mvp
Homologene
FAMILY vault family of protein
CATEGORY structural protein , RNA associated , transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,vault
intracellular,nuclear envelope,pore
basic FUNCTION
  • cytoplasmic ribonucleoprotein complexes
  • secretory and excretory functions, mediating drug resistance via the nucleocytoplasmic transport
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text nucleocytoplasmic transport
    PATHWAY
    metabolism drug
    signaling
    a component constituent of vault: multisubunit structure,involved in nucleocytoplasmic transport
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • putative PTPN11 substrate ( regulation of MVP tyrosyl phosphorylation may play an important role in cell survival signaling)
  • cooperating with Ras for optimal EGF-induced Elk-1 activation and required for cell survival
  • KPNA7 interaction was confirmed for MVP and ZNF414, with distinct roles as novel regulators of pancreatic cancer cell growth
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in acute myeloid leukemia resistant to chemotherapy
    tumoral     --over  
    in multidrug-resistant cancer cells (AML)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS