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FLASH GENE
Symbol MED17 contributors: mct - updated : 02-12-2010
HGNC name mediator complex subunit 17
HGNC id 2375
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • mediator complex subunit 17 family
    • CATEGORY transcription factor , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • global coactivator for the nuclear receptor family
  • multiprotein transcriptional coactivator required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factors
  • core Mediator subunits MED1 and MED17 are recruited to the CDKN1A locus
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription coactivator
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • omponent of the CRSP coactivation complex, mediating, import, activator-dependent recruitment of RNA PolII
  • also component of the TRAP/SMCC complex
  • central component of Mediator, required for the structure and integrity of the complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNA polymerase POLII via its C-terminal domain
  • activating SP1
  • vitamin D receptor
  • thyroid hormone receptor
  • TP53
  • viral transcription factor VP16
  • direct contact between RELA and Mediator, through the MED17 subunit and the TA1 and TA2 regions of RELA
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MICCH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS