Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MED17 contributors: mct - updated : 02-12-2010
HGNC name mediator complex subunit 17
HGNC id 2375
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Hearing/Equilibriumear   highly
Lymphoid/Immunespleen   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • mediator complex subunit 17 family
    • CATEGORY transcription factor , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • global coactivator for the nuclear receptor family
  • multiprotein transcriptional coactivator required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factors
  • core Mediator subunits MED1 and MED17 are recruited to the CDKN1A locus
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription coactivator
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • omponent of the CRSP coactivation complex, mediating, import, activator-dependent recruitment of RNA PolII
  • also component of the TRAP/SMCC complex
  • central component of Mediator, required for the structure and integrity of the complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNA polymerase POLII via its C-terminal domain
  • activating SP1
  • vitamin D receptor
  • thyroid hormone receptor
  • TP53
  • viral transcription factor VP16
  • direct contact between RELA and Mediator, through the MED17 subunit and the TA1 and TA2 regions of RELA
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MICCH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS