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FLASH GENE
Symbol UNC45B contributors: mct - updated : 10-12-2020
HGNC name unc-45 homolog B (C. elegans)
HGNC id 14304
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal tetratricopeptide repeat domain that binds to Hsp90
  • a central domain composed of armadillo repeats, interacting with myosin and inhibiting the actin translocation function of myosin
  • C-terminal UCS domain, which is also comprised of helical armadillo repeats, interacts with myosin , and is responsible for the chaperone-like properties of the UNC45B
    • HOMOLOGY
    interspecies homolog to rattus Unc45b (94.6 pc)
    homolog to murine Unc45b (94.9 pc)
    Homologene
    FAMILY
  • UCS family of myosin chaperones
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    text
  • Shuttling of the chaperones UNC45B and HSPAA1 between the A band and the Z line of the myofibril (Etard 2008)
  • in adulthood, UNC45B is stored at the Z-disk
    • basic FUNCTION
  • may play a role in sarcomere formation and organisation during muscle cell development
  • playing a role in myoblast fusion
  • may act as co-chaperone for HSP90
  • may be necessary for proper folding of myosin
  • is a cytosolic protein that forms a stable complex with HSP90AA1, selectively binds the unfolded conformation of the myosin motor domain, and promotes motor domain folding
  • myosin-specific chaperone that, together with the general heat shock protein HSP90AA1, is involved in myosin assembly
  • UNC45B is a molecular chaperone that mediates the folding of thick-filament myosin during sarcomere formation; however, UNC45B may also mediate specific functions of non-muscle myosins (NMMs)
  • is a multidomain molecular chaperone that is essential for the proper folding and assembly of myosin into muscle thick filaments
  • is essential for sarcomeric organization and muscle function
  • UNC45B provides substrate specificity for the partner chaperones during late stages of myofibrillogenesis
  • myosin-specific chaperone involved in assembly, function, and maintenance of type II myosin, facilitating assembly and function of striated muscle contraction
  • role of UNC45B as a key regulator of myofibril maintenance and function
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text
  • cytoskeleton organization
  • myogenesis of skeletal muscles
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • chaperone UNC45B inhibits the actin translocation function of myosin
  • UNC45B in the earliest stages of muscle development that is independent of muscle muscle myosin heavy chain (mMHC) folding
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ADCC7 , MUNC45BD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS