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FLASH GENE

Symbol

CLSTN3

contributors: - updated : 24-08-2007

HGNC name	calsyntenin 3
HGNC id	18371

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly   nerve       highly Reproductive male system prostate     moderately   male system testis     highly Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a cytoplasmic synaptic Ca2+ binding domain
	two cadherin domains

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to rattus Cstn3
	ortholog to murine Clstn3
	homolog to Drosophila calsyntenin-1
	homolog to C.elegans B0034.3a

Homologene

FAMILY

CATEGORY

adhesion , regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I membrane protein

basic FUNCTION

modulating calcium-mediated postsynaptic signals

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	calcium Ca2+

protein

interacting with APP (coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS