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FLASH GENE

Symbol

CLSTN2

contributors: mct/ - updated : 24-08-2007

HGNC name	calsyntenin 2
HGNC id	17448

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	632.89 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_022131 17 - 4882 NP_071414 - 955 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral lobe temporal lobe moderately Homo sapiens   brain forebrain cerebral lobe temporal lobe moderately Homo sapiens Reproductive female system breast mammary gland       male system prostate         male system testis     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a cytoplasmic synaptic Ca2+ binding domain
	two cadherin domains

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Clstn2
	homolog to rattus Cstn2
	homolog to Drosophila calsyntenin-1
	homolog to C.elegans B0034.3a

Homologene

FAMILY

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I membrane protein

basic FUNCTION

modulating calcium-mediated postsynaptic signals

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein

interacting with APP (coordinated metabolism of alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS