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FLASH GENE
Symbol CLSTN2 contributors: mct/ - updated : 24-08-2007
HGNC name calsyntenin 2
HGNC id 17448
Location 3q23      Physical location : 139.654.026 - 140.286.917
Synonym name
  • alcadein gamma
  • cadherin-related family member 13
    • Synonym symbol(s) CS2, CSTN2, FLJ39113, FLJ39499, MGC119560, alcagamma, CDHR13
    DNA
    TYPE functioning gene
    STRUCTURE 632.89 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 4882 - 955 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral lobetemporal lobemoderately Homo sapiens
     brainforebraincerebral lobetemporal lobemoderately Homo sapiens
    Reproductivefemale systembreastmammary gland  
     male systemprostate   
     male systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cytoplasmic synaptic Ca2+ binding domain
  • two cadherin domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Clstn2
    homolog to rattus Cstn2
    homolog to Drosophila calsyntenin-1
    homolog to C.elegans B0034.3a
    Homologene
    FAMILY
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • modulating calcium-mediated postsynaptic signals
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • interacting with APP (coordinated metabolism of alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS