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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CMTM3

contributors: mct - updated : 11-07-2019

HGNC name	CKLF-like MARVEL transmembrane domain containing 3
HGNC id	19174

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   significantly methylated in Colorectal cancer tissues when compared with adjacent normal colorectal tissues tumoral     --low   in gastric and testicular cancer tumoral     --low   in esophageal squamous cell carcinoma (ESCC) patients tumoral     --low   significantly elevated promoter methylation of CMTM3 in laryngeal squamous cell carcinoma tissues compared with their adjacent tissues tumoral     --low   due to promoter hypermethylation contributed to the proliferation and migration of oral squamous cell carcinoma cells tumoral     --low   dramatically downregulated in primary gastric cancer tissues

Susceptibility

Variant & Polymorphism

Candidate gene	is a candidate marker for prognosis of gastric cancer in the clinic
Marker	with SSTR2, and MDFI having a potential role as biomarkers for colorectal cancer
	CMTM3 protein expression in resected esophageal tumors may present an effective prognostic biomarker 5)
	elevated CMTM3 methylation is a risk factor in male laryngeal squamous cell carcinoma patients, especially in the patients with age over 55 years and with smoking behavior
	secreted CMTM3 in urine is likely a diagnostic marker for prostate cancer
	is an independent prognostic factor for the evaluation of the survival of oral squamous cell carcinoma patients
Therapy target
	System Type Disorder Pubmed cancer urinary   CMTM3 may be a potentially target for therapeutic strategy in clear cell renal cell carcinoma (PMID: 23907292)

ANIMAL & CELL MODELS