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FLASH GENE
Symbol CMTM3 contributors: mct - updated : 11-07-2019
HGNC name CKLF-like MARVEL transmembrane domain containing 3
HGNC id 19174
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transmembrane domains which are included in a central MARVEL domain
  • one leucine zipper and two LXXLL motifs
    • HOMOLOGY
    interspecies ortholog to murine Cklfsf3
    intraspecies homolog to CKLFSF5
    Homologene
    FAMILY chemokine-like factor gene superfamily
    CATEGORY chaperone/stress , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nuclear envelope
    text
  • expressed ubiquitously except for plasma cells
  • novel secretory protein released via exosomes
    • basic FUNCTION
  • scaffolding for signaling proteins such as BASH, Btk, and ERK at the ER and nuclear membrane and facilitating ERK activation by signaling from cell-surface receptors
  • may play some roles in the maturation and maintenance of the male reproduction
  • play important roles in the immune system and participate in tumorigenesis
  • may play an integral role in the development and progression of prostate cancer
  • regulates migration and invasion of gastric cancer cells
  • is a tumor suppressor gene, plays an important role in the suppression of cell growth and apoptosis
  • new regulatory function for CMTM3 in angiogenesis
  • CMTM3 mediates cell-cell adhesion at adherens junctions and contributes to the control of vascular sprouting
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • colocalizing with BLNK
  • repressing KLKL3
  • CMTM3 is involved in CDH5 turnover and is a regulator of the cell surface pool of CDH5
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly methylated in Colorectal cancer tissues when compared with adjacent normal colorectal tissues
    tumoral     --low  
    in gastric and testicular cancer
    tumoral     --low  
    in esophageal squamous cell carcinoma (ESCC) patients
    tumoral     --low  
    significantly elevated promoter methylation of CMTM3 in laryngeal squamous cell carcinoma tissues compared with their adjacent tissues
    tumoral     --low  
    due to promoter hypermethylation contributed to the proliferation and migration of oral squamous cell carcinoma cells
    tumoral     --low  
    dramatically downregulated in primary gastric cancer tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • is a candidate marker for prognosis of gastric cancer in the clinic
    • Marker
  • with SSTR2, and MDFI having a potential role as biomarkers for colorectal cancer
  • CMTM3 protein expression in resected esophageal tumors may present an effective prognostic biomarker 5)
  • elevated CMTM3 methylation is a risk factor in male laryngeal squamous cell carcinoma patients, especially in the patients with age over 55 years and with smoking behavior
  • secreted CMTM3 in urine is likely a diagnostic marker for prostate cancer
  • is an independent prognostic factor for the evaluation of the survival of oral squamous cell carcinoma patients
    • Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    CMTM3 may be a potentially target for therapeutic strategy in clear cell renal cell carcinoma (PMID: 23907292)
    ANIMAL & CELL MODELS