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FLASH GENE

Symbol

CMTM3

contributors: mct - updated : 11-07-2019

HGNC name	CKLF-like MARVEL transmembrane domain containing 3
HGNC id	19174

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	9.90 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_144601 6 splicing 2439 NP_653202 19.7 182 leukocytes,placenta,testis 2017 28428220 encoding the same isoform that variants 1,2 and 3 NM_181553 5 splicing 1901 NP_853531 19.7 182 - 2017 28428220 differring in the 5' UTR encoding the same isoform that variants 1,2 and 3 variant 3 - splicing 2035 19.7 182 - 2017 28428220 differring in the 5' UTR encoding the same isoform that variants 1,2 and 3 variant 4 - splicing initiation site 1813 10.1 96 - 2017 28428220 differring in the 5' UTR and the 5' coding region NM_001363918 6 - 2333 NP_001350847 - 182 - 2017 28428220 NM_001363923 6 - 2366 NP_001350852 - 182 - 2017 28428220

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     predominantly Homo sapiens   male system male genital tract     predominantly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four transmembrane domains which are included in a central MARVEL domain
	one leucine zipper and two LXXLL motifs

HOMOLOGY

interspecies

ortholog to murine Cklfsf3

intraspecies

homolog to CKLFSF5

Homologene

FAMILY

chemokine-like factor gene superfamily

CATEGORY

chaperone/stress , signaling

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm
	intracellular,nuclear envelope
text	expressed ubiquitously except for plasma cells
	novel secretory protein released via exosomes

basic FUNCTION	scaffolding for signaling proteins such as BASH, Btk, and ERK at the ER and nuclear membrane and facilitating ERK activation by signaling from cell-surface receptors
	may play some roles in the maturation and maintenance of the male reproduction
	play important roles in the immune system and participate in tumorigenesis
	may play an integral role in the development and progression of prostate cancer
	regulates migration and invasion of gastric cancer cells
	is a tumor suppressor gene, plays an important role in the suppression of cell growth and apoptosis
	new regulatory function for CMTM3 in angiogenesis
	CMTM3 mediates cell-cell adhesion at adherens junctions and contributes to the control of vascular sprouting

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	colocalizing with BLNK
	repressing KLKL3
	CMTM3 is involved in CDH5 turnover and is a regulator of the cell surface pool of CDH5

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   significantly methylated in Colorectal cancer tissues when compared with adjacent normal colorectal tissues tumoral     --low   in gastric and testicular cancer tumoral     --low   in esophageal squamous cell carcinoma (ESCC) patients tumoral     --low   significantly elevated promoter methylation of CMTM3 in laryngeal squamous cell carcinoma tissues compared with their adjacent tissues tumoral     --low   due to promoter hypermethylation contributed to the proliferation and migration of oral squamous cell carcinoma cells tumoral     --low   dramatically downregulated in primary gastric cancer tissues

Susceptibility

Variant & Polymorphism

Candidate gene	is a candidate marker for prognosis of gastric cancer in the clinic
Marker	with SSTR2, and MDFI having a potential role as biomarkers for colorectal cancer
	CMTM3 protein expression in resected esophageal tumors may present an effective prognostic biomarker 5)
	elevated CMTM3 methylation is a risk factor in male laryngeal squamous cell carcinoma patients, especially in the patients with age over 55 years and with smoking behavior
	secreted CMTM3 in urine is likely a diagnostic marker for prostate cancer
	is an independent prognostic factor for the evaluation of the survival of oral squamous cell carcinoma patients
Therapy target
	System Type Disorder Pubmed cancer urinary   CMTM3 may be a potentially target for therapeutic strategy in clear cell renal cell carcinoma (PMID: 23907292)

ANIMAL & CELL MODELS