SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,nucleus
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| text
| type II transmembrane protein |
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CKAP4 palmitoylation by DHHC2 is required for its trafficking from the ER to the plasma membrane and for its nuclear localization) |
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exclusively localized in sheet-like ER membranes, typical structures of the rough ER, and plays a pivotal role in the static interaction with MTs |
| basic FUNCTION
| involved in linking the ER to microtubules, and required for protein transport from the ER to the golgi complex |
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may contribute to the functional regulation of the plasminogen activation system in the vessel wall |
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important epithelial cell receptor for APF, Antiproliferative factor (APF) is a sialoglycopeptide that is secreted by bladder cells from interstitial cystitis patients, a potent inhibitor of both normal bladder epithelial and bladder carcinoma cell proliferation |
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CKAP4-mediated stable anchoring of the ER to microtubules is required to maintain the spatial distribution of the ER during interphase and this interaction is abolished by phosphorylation of CKAP4 during mitosis |
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role of CKAP4 as an SFTPA1 receptor protein localized on the surface of lung type II cells |
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role for TP73 and CKAP4 in supporting cellular proliferation through the transcriptional activation of the genes involved in G(1)-S and G(2)-M progression |
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reversibly palmitoylated and phosphorylated protein that links the ER to the cytoskeleton |
