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FLASH GENE
Symbol CDC26 contributors: mct - updated : 08-09-2021
HGNC name cell division cycle 26
HGNC id 17839
Location 9q32      Physical location : 116.029.289 - 116.037.869
Synonym name
  • chromosome 9 open reading frame 17
  • anaphase-promoting complex subunit 12
  • cell division cycle 26 homolog
  • Synonym symbol(s) HGNC17839, C9orf17, ANAPC12, APC1
    DNA
    TYPE functioning gene
    STRUCTURE 8.59 kb     0 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 871 - 85 - 2001 11285280
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region (residues 124) is highly conserved from yeast to mammals (
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to S.cerevisiae Cdc26
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may function as a cell cycle-regulated ubiquitin-protein ligase
  • CDC26 is a non-essential heat-inducible protein in budding yeast and is required for the growth at high temperatures (
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of cell cycle anaphase-promoting complex (APC)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDC26 stabilizes the structure of CDC16, a core TPR protein required for APC integrity
  • LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C
  • CDC26 is a target of LATS1/2
  • LATS1-mediated phosphorylation of the T7 residue of CDC26 disrupts its interaction with CDC16
  • cell & other
    REGULATION
    Other cell-cycle regulated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS