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FLASH GENE

Symbol

PPOX

contributors: mct - updated : 22-05-2013

HGNC name	protoporphyrinogen oxidase
HGNC id	9280

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	two transcripts encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000309 13 - 1716 NP_000300 50.6 477 - 2008 18191920 NM_001122764 13 - 1777 NP_001116236 50.6 477 - 2008 18191920

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Endocrine neuroendocrine pituitary     highly   pancreas         Lymphoid/Immune thymus       highly   tonsils       highly Reproductive female system uterus     highly Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal independently functioning signal for mitochondrial targeting, and all the information required for efficient import is contained within the first 250 AAs of N-terminus

conjugated

FlavoP

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

protoporphyrinogen oxidase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,mitochondria,interspace
	intracellular,cytoplasm,organelle,membrane
text	nucleus-encoded flavoprotein strongly associated with the outer surface of the inner mitochondrial membrane

basic FUNCTION	protoporphyrinogen oxidase, catalyzing protoporphyrin formation, seventh step of porphyrin biosynthesis
	mitochondrial inner membrane protein, converting protoporphyrinogen IX to protoporphyrin IX in the heme biosynthetic pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	one FAD per homodimer

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

VP1

related resource

MITOP database

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS