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FLASH GENE
Symbol SLC17A9 contributors: mct/pgu - updated : 08-09-2010
HGNC name solute carrier family 17, member 9
HGNC id 16192
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 12 putative transmembrane domains
    • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
    • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • vesicular nucleotide transporter and should lead to the elucidation of the molecular mechanism of ATP secretion in purinergic signal transmission
  • SLC17A9-dependent vesicular exocytosis in ATP release and T cell activation
  • involved in vesicular storage of ATP and exocytosis of ATP, and plays a critical role in both vesicular exocytosis of ATP and TCR signaling during T cell activation
  • contributed to ATP vesicle formation and regulated ATP release
  • existence of an SLC17A9-dependent ATP-enriched vesicular pool in biliary epithelium that undergoes regulated exocytosis to initiate purinergic signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS