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FLASH GENE
Symbol ROMO1 contributors: mct - updated : 21-03-3016
HGNC name reactive oxygen species modulator 1
HGNC id 16185
Location 20q11.23      Physical location : 34.287.231 - 34.288.901
Synonym name
  • homolog of mouse RIKEN 2010100O12 gene
  • chromosome 20 open reading frame 52
  • mitochondrial targeting GXXXG protein
  • glyrichin
    • Synonym symbol(s) bA353C18.2, C20orf52, MTGMP, MGC111180
    DNA
    TYPE functioning gene
    STRUCTURE 1.67 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 477 8 79 - 2008 18313394
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • transmembrane domain
    • HOMOLOGY
    interspecies homolog to murine RIKEN 2010100O12
    Homologene
    FAMILY
  • MGR2 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    text
  • localized in the mitochondria 2)
    • basic FUNCTION
  • may play an important role in redox signaling in cancer cells
  • integral mitochondrial inner-membrane protein that coordinately regulates mitochondrial morphology and cell proliferation
  • ROMO1-derived ROS play potentially an important role in apoptotic cell death triggered by withdrawal of cell survival factors
  • recruits BCL2L1 to reduce the mitochondrial membrane potential, resulting in ROS production and apoptotic cell death
  • molecular bridge between TNF-alpha signaling and the mitochondria for ROS production that triggers TNF-alpha-mediated apoptosis, as well as a novel target in the development of anti-inflammatory agents that block the origin of ROS production
  • subsequently triggers SKP2-mediated ubiquitylation and degradation of MYC
  • is responsible for a serum deprivation-induced increase in reactive oxygen species (ROS)
  • involved in generation of reactive oxygen species in mitochondria
  • localized in the mitochondria and mediates mitochondrial ROS production through complex III of the mitochondrial electron transport chain
  • mediates mitochondrial ROS production and apoptosis induced by oxidative stress in lung epithelial cells
  • is a new translocase constituent with an exceptionally short half-life
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ROMO1 and B-cell lymphoma-extra large (BCL2L1) are directly associated with TNF-alpha-induced ROS production
  • while ROMO1 is dispensable for general protein import along the presequence pathway, it participates in the dynamics of TIMM21 during respiratory chain biogenesis and is specifically required for import of YME1L
    • cell & other
    REGULATION
    induced by upregulated MYC protein, which triggers the G1-S phase progression in response to growth-stimulatory signals, induces reactive oxygen species modulator 1 (ROMO1) expression
    oxidative stress playing an important role in oxidative stress-induced mitochondrial ROS production and
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in brain tumor cell lines and tumor tissues
    constitutional     --over  
    results in mitochondrial fragmentation and release of mitochondrial Smac/Diablo to the cytosol with no effect on apoptosis
    constitutional     --over  
    correlates with epithelial cell death in patients with idiopathic pulmonary fibrosis (IPF)
    tumoral     --over  
    in a variety of cancer cell lines and inhepatocellular carcinoma tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS