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FLASH GENE
Symbol ABHD12 contributors: mct - updated : 30-08-2017
HGNC name abhydrolase domain containing 12
HGNC id 15868
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • serine esterase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • with MGLL, and ABHD6, display distinct subcellular distributions, suggesting that they may control different pools of 2-AG (2-arachidonoylglycerol) in the nervous system
  • membrane-bound enzyme that exhibits monoacylglycerol (MAG) lipase activity
  • performs an essential function in the peripheral and central nervous systems and in the eye
  • could contribute to the metabolism of the endogenous cannabinoid 2-arachidonoylglycerol (2-AG) in the nervous system
  • functions as a major lysophosphatidylserine lipase in the mammalian nervous system
  • metabolic serine hydrolases ABHD16A and ABHD12 are major lipases that biosynthesize and degrade Lysophosphatidylserine (lyso-PS), respectively in the brain
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PHARC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Abhd12 -/- mice display massive increases in a rare set of very long chain LPS lipids that have been previously reported as Tlr2 activators