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FLASH GENE
Symbol MEF2B contributors: mct/npt/pgu - updated : 15-03-2010
HGNC name myocyte enhancer factor 2B
HGNC id 6995
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • MADS,(yeast Mcm1, plant homeotic Agamous and Deficiens, human Serum response factor) domain
  • a MEF2 specific domain and forming with it a DNA binding and dimerization domains
    • HOMOLOGY
    intraspecies paralog to MEF2A
    Homologene
    FAMILY
  • MEF2 family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • associating with HDAC4, HDAC in regulation of skeletal myogenesis
  • important for smooth muscle myosin heavy chain gene regulation
  • mediating calcium-dependent transcription of the interleukin-2 gene in T lymphocytes
  • implicated in neuronal activity-dependent cell survival, and may be regulate excitatory synapse number and postsynaptic differentiation of dendrites
  • implicated in the regulation of adult bone mass
  • involved in the inducible expression of NOX1/NADPH oxidase, a vascular superoxide-producing enzyme
  • important component in GNA13-mediated angiogenesis
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to myocyte-specific enhancer
    RNA
    small molecule
    protein
  • binding to TWIST to inhibit myogenesis
  • binding to members of the MyoD family of transcriptional activator
  • interacting with NFATC2
  • binding SUV39H1 and CABIN1 (targeting its promoter in a calcium-dependent manner)
  • cooperates with CREBBP and EP300 in acetylating histones
    • cell & other
    REGULATION
    repressed by HDAC4 through multiple independent repressive domains
    Other negatively regulated by MITR in association with HDAC1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    of endogenous GNA13 and MEF2 proteins in endothelial cells reduced cell proliferation and capillary tube formation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS