Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

RBCK1

contributors: mct/npt/pgu - updated : 27-06-2017

HGNC name	RanBP-type and C3HC4-type zinc finger containing 1
HGNC id	15864

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PGBM1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   mediates the development of myocyte hypertrophy, and promotes cardiac myocyte hypertrophy tumoral         silencing of RBCK1 impairs lung tumor growth

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular aquired heart failure PRKCB1-RBCK1 interaction would serve as a potential therapeutic target to treat pathological cardiac hypertrophy cancer     is likely an attractive target for cancer therapy

ANIMAL & CELL MODELS

Hoil-1-deficient mice exhibit amylopectin-like deposits in the myocardium, pathogen-specific immunodeficiency, but minimal signs of hyper-inflammation