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FLASH GENE
Symbol KCNJ9 contributors: mct - updated : 12-05-2009
HGNC name potassium inwardly-rectifying channel, subfamily J, member 9
HGNC id 6270
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two membrane-spanning domains
  • an amphipatic region pore, including the P domain with the K+ channel signature
  • an ATP-binding regulatory domain
  • a C-terminal intracellular domain with binding sites for NTRK2 and NCAM1
    • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • inward rectifier-type potassium channel family
  • subfamily J
    • CATEGORY receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • G protein coupled, potassium non voltage-gated channel, inwardly rectifying
  • having a critical role for depotentiation, one form of excitatory synaptic plasticity
  • having a decisive role in regulating NCAM1-dependent neurite outgrowth
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • associates with another G-protein-activated potassium channel (GIRK1) to form a heteromultimeric pore-forming complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly binds to the neural cell adhesion molecule (NCAM1) and KCNJ9
    • cell & other
    REGULATION
    Other regulated by NTRK2 (regulates the cell surface expression of KCNJ9)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS