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FLASH GENE

Symbol

KCNJ9

contributors: mct - updated : 12-05-2009

HGNC name	potassium inwardly-rectifying channel, subfamily J, member 9
HGNC id	6270

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
text	arranged in tandem with KCNJ10
STRUCTURE	7.85 kb     3 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004983 3 - 3029 NP_004974 43.9 393 - 2000 10913335

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus         Homo sapiens Nervous brain         Reproductive male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular smooth muscularis mucosa (tractus digestif)     Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two membrane-spanning domains
	an amphipatic region pore, including the P domain with the K+ channel signature
	an ATP-binding regulatory domain
	a C-terminal intracellular domain with binding sites for NTRK2 and NCAM1

mono polymer

homomer , tetramer

HOMOLOGY

Homologene

FAMILY	inward rectifier-type potassium channel family
	subfamily J

CATEGORY

receptor , transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	G protein coupled, potassium non voltage-gated channel, inwardly rectifying
	having a critical role for depotentiation, one form of excitatory synaptic plasticity
	having a decisive role in regulating NCAM1-dependent neurite outgrowth

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

associates with another G-protein-activated potassium channel (GIRK1) to form a heteromultimeric pore-forming complex

INTERACTION

DNA

RNA

small molecule

protein

directly binds to the neural cell adhesion molecule (NCAM1) and KCNJ9

cell & other

REGULATION

Other

regulated by NTRK2 (regulates the cell surface expression of KCNJ9)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS