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FLASH GENE
Symbol BOP1 contributors: - updated : 20-09-2006
HGNC name block of proliferation 1
HGNC id 15519
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Digestiveliver   highly
Endocrinepancreas   highly
Nervousbrain   highly
Respiratorylung   highly
Skin/Tegumentskin   highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven WD repeats
HOMOLOGY
interspecies ortholog to murine Bop1
homolog to Drosophila EG.S2C10.1
homolog to C.elegans Y48B6A.1
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleolus
text transient overexpression of BOP1 in cells increased the percentage of multipolar spindles
basic FUNCTION
  • functioning as a regulator of growth
  • may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS