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FLASH GENE

Symbol

BCL11B

contributors: mct/shn - updated : 12-09-2017

HGNC name	B-cell CLL/lymphoma 11B (zinc finger protein)
HGNC id	13222

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IMD49

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     translocated with TLX3 in t(5,14)(q35;q32.2) in B cell acute lymphoblastic leukemia tumoral   translocation     t(2;14)(q34;q32) (fusion of BCL11B and IKZF2) in adult T-cell leukemia/lymphoma (ATLL) tumoral     --low   is a key event in the multistep progression of ATLL (adult T-cell leukemia/lymphoma) leukemogenesis

Susceptibility

Variant & Polymorphism

Candidate gene	may be considered a new candidate for targeted gene therapy in T-cell malignancies
Marker
Therapy target

ANIMAL & CELL MODELS

profound apoptosis in the thymus of neonatal Bcl11b-/- mice and adult mice show a block at the CD4-CD8- double-negative stage of thymocyte development