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FLASH GENE

Symbol

NBL1

contributors: mct - updated : 13-09-2014

HGNC name	neuroblastoma, suppression of tumorigenicity 1
HGNC id	7650

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

cystine-knot domain

HOMOLOGY

interspecies	homolog to mammalian dan
	homolog to murine NbL1

Homologene

FAMILY

CATEGORY

transcription factor , tumor suppressor

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	is a novel autocrine/paracrine factor that modulates GNRHR function in pituitary gonadotropes
	is indispensable for NODAL expression in the in the lateral plate mesoderm (LPM) and for Lefty-1 expression in the notochord
	might act synergistically with NODAL
	plays an essential role in the establishment of the L-R axis by inhibiting BMP signaling around the node

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	UBQLN1/NBL1 complex might play a crucial role in the regulation of the cell cycle progression
	inhibited BMP signaling but not NODAL signaling
	specifically can antagonize BMP2 and BMP4 and modulates the actions of GDF9, BMP2, and BMP4 ovary

cell & other

REGULATION

activated by

mRNA expression in granulosa cells was up-regulated by oocyte-derived growth differentiation factor 9 (GDF9)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   correlated with prostate carcinoma progression

Susceptibility

to neuroblastoma

Variant & Polymorphism

Candidate gene
Marker	NBL1 and anillin are promising markers for pancreatic carcinoma molecular diagnostics
	NBL1 might be a candidate tumor marker for prostate carcinoma in addition to PSA
Therapy target

ANIMAL & CELL MODELS