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FLASH GENE
Symbol ASNA1 contributors: mct - updated : 24-05-2017
HGNC name arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
HGNC id 752
Location 19p13.13      Physical location : 12.848.305 - 12.859.138
Synonym name
  • 40 kDa ATPase subunit of TMD recognition complex (TRC)
  • Transmembrane Recognition Complex subunit of 40 kDa
  • Synonym symbol(s) ARSA1, ARSA-I, TRC40, GET3
    EC.number 3.6.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 10.87 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1298 - 348 - 1998 10696239
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver   moderately
     salivary gland   highly
    Lymphoid/Immunethymus   highly
    Nervousbrain   highly
     nervecranial nerve  highly
    Reproductivefemale systembreastmammary gland highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone  highly
    cell lineage
    cell lines
  • malignant melanoma
  • breast cancer
  • fluid/secretion
  • moderately in blood
  • at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • FFAT-like motifs
  • mono polymer homomer , dimer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Asna1 (95.7 pc)
    homolog to murine Asna1 (99.7 pc)
    Homologene
    FAMILY
  • arsA ATPase family
  • CATEGORY enzyme , transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus,nucleolus
    intracellular,nuclear envelope
    basic FUNCTION
  • acting as an anion transporting ATPase
  • catalysing the extrusion of arsenite
  • representing an integral component of a posttranslational pathway of membrane protein insertion whose targeting is mediated by TRC
  • interacting posttranslationally with tail-anchored proteins in a TMD-dependent manner for delivery to a proteinaceous receptor at the ER membrane
  • acting as a modulator of insulin signaling
  • playing a crucial role in biogenesis of at least one essential tail-anchored protein
  • ASNA1-mediated pathway of membrane insertion of SERP1 and SEC61B may relate to functions of these proteins in the ER stress response
  • cytosolic ATPase that are responsible for two different ATP-dependent pathways of tail-anchored protein biogenesis
  • can mediate membrane insertion of SERP1 and SEC61B without the participation of other cytosolic proteins by a mechanism that depends on the presence of ATP or ADP and a protease-sensitive receptor in the ER membrane
  • role for GET4/UBL4A in recycling ASNA1 from the ER membrane at the end of the targeting reaction
  • cytosolic ATPase with a central role in the post-translational targeting pathway of tail-anchored (TA) proteins to the endoplasmic reticulum (ER) membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport , detoxification
    text
  • arsenical resistance
  • arsenical transmembrane transporter
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide, other,
  • ATP
  • arsenite
  • protein
  • binding to metallothionein II
  • BAG6 is a previously unknown interacting partner of ASNA1
  • WRB, also known as congenital heart disease protein 5 (CHD5), as the ER membrane receptor for ASNA1
  • CALN1 and CABP7 are nonclassical type II tail-anchored proteins that are post-translationally inserted into the endoplasmic reticulum membrane via an association of a 23AA-long transmembrane domain (TMD) with the ASNA1 chaperone complex
  • GET4-mediated regulation of ATP hydrolysis by ASNA1 is essential to efficient tail-anchor (TA)-protein targeting
  • ASNA1 function requires an ER receptor, the WRB protein (tryptophan-rich basic protein), homologous to yeast Get1, in combination with CAMLG (calcium-modulating cyclophilin ligand)
  • CAMLG, together with WRB, constitutes the mammalian receptor for the Transmembrane Recognition Complex subunit of 40 kDa (ASNA1)
  • cell & other
    REGULATION
    activated by arsenite
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS