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FLASH GENE
Symbol AP4M1 contributors: mct/npt - updated : 25-08-2009
HGNC name adaptor-related protein complex 4, mu 1 subunit
HGNC id 574
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , tetramer
HOMOLOGY
interspecies ortholog to murine Ap4m1
Homologene
FAMILY
  • adaptor complexes medium subunit family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in the recognition and the sorting of cargo proteins with tyrosin-based motifs from the trans-Golgi network to the endosomal-lysosomal system
  • involved in intracellular trafficking of glutamate receptors (Verkerk 2009)
    • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramerized with AP4B1, AP4E1, AP4S1
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding specifically to tyrosin-based sorting signal
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG50
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS