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FLASH GENE
Symbol AP4M1 contributors: mct/npt - updated : 25-08-2009
HGNC name adaptor-related protein complex 4, mu 1 subunit
HGNC id 574
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   lowly
Reproductivemale systemtestis  highly
Respiratorylung   lowly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , tetramer
HOMOLOGY
interspecies ortholog to murine Ap4m1
Homologene
FAMILY
  • adaptor complexes medium subunit family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in the recognition and the sorting of cargo proteins with tyrosin-based motifs from the trans-Golgi network to the endosomal-lysosomal system
  • involved in intracellular trafficking of glutamate receptors (Verkerk 2009)
    • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramerized with AP4B1, AP4E1, AP4S1
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding specifically to tyrosin-based sorting signal
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG50
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS