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FLASH GENE

Symbol

ALDH3A2

contributors: mct - updated : 13-07-2016

HGNC name	aldehyde dehydrogenase 3 family, member A2
HGNC id	403

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive esophagus       highly   mouth tongue     highly Endocrine pancreas         Respiratory respiratory tract trachea     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		globular		Hydrophobic
STRUCTURE

motifs/domains

hydrophobic C terminal sequence necessary for microsomal membrane anchoring, and a previously unrecognized element in its C-terminal region, a 'gatekeeper' helix, which extends over the adjacent subunit, controlling the access to the substrate cavity and helping orientate both substrate cavities towards the membrane surface

HOMOLOGY

interspecies	homolog to murine Aldh3a2
	homolog to yeast Hfd1

Homologene

FAMILY

aldehyde dehydrogenase, class III (fatty alcohol oxidoreductase) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,peroxisome
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic,microsome
	intracellular,nucleus

basic FUNCTION	catalyzing the oxidation of medium-chain (fatty) aliphatic and aromatic aldehydes to fatty acids
	detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation
	fatty aldehyde dehydrogenase (FALDH)that exhibits activity toward saturated and unsaturated aliphatic aldehydes of 6–24 carbons in length
	is the FALDH active within the S1P metabolic pathway
	ALDH3A2 are responsible for conversion of the S1P degradation product hexadecenal to hexadecenoic acid
	functions to oxidize fatty alcohols as a component of the fatty alcohol:NAD oxidoreductase (FAO) enzyme complex
	is a ubiquitous enzyme involved in lipid detoxification

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SLS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in patients >40 years, and Granulosa-Lutein cell ALDH3A2 expression levels correlate with age, cause of infertility, and ovarian response to stimulation

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Aldh3a2(-/-) mice replicated some aspects of SLS symptoms, especially at the basal layer of the epidermis