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FLASH GENE
Symbol HEBP1 contributors: - updated : 14-09-2006
HGNC name heme binding protein 1
HGNC id 17176
Location 12p13.2      Physical location : 13.127.800 - 13.153.243
Synonym symbol(s) HBP, HEBP, F2L
DNA
TYPE functioning gene
STRUCTURE 25.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrineneuroendocrinepituitary  highly
 parathyroid   highly
Hearing/Equilibriumear   highly
Lymphoid/Immunethymus    
Reproductivemale systemprostate   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like
    • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine Hebp1
    homolog to chicken soul
    homolog to Rattus Rn.6886
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • intracellular tetrapyrrole-binding protein may be involved in heme protein biosynthesis
  • promotes calcium mobilization and chemotaxis in monocytes and dendritic cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS circadian
    PATHWAY
    metabolism porphyrin/heme
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    heme, free porphyrins and methylprotoporphyrin
    protein binds and activates FPRL2 in the low nanomolar range, which triggers intracellular calcium release and inhibition of cAMP accumulation
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    chicken and murine models