SUBCELLULAR LOCALIZATION
| intracellular
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,cytoplasm,cytoskeleton,microtubule
|
text
| peripheral membrane-associated protein that accumulates at the Golgi apparatus (Schaefer 2007) |
|
is concentrated at the Golgi membrane in an Arf1-regulated manner and facilitates both nucleation rates and polymerization speed of Golgi-derived microtubules |
basic FUNCTION
| involved in the pathway leading to correctly folded beta-tubulin from folding intermediates and in maintenance of microtubule in motor axons |
|
implicated in microtubule dynamics through regulation of tubulin heterodimer dissociation (Kortazar 2007) |
|
tubulin chaperone with critical role in axonal tubulin routing from the Golgi apparatus (Schaefer 2007) |
|
plays a critical role in the formation of the parathyroid opens (Parvari 2007) |
|
required for the normal development and function of neuromuscular synapses and promotes microtubule formation (Jin 2009) |
|
is required for the folding of alpha-tubulin, alpha/beta-tubulin dimerization, and subsequent heterodimer polymerization into microtubules, which are major components of the cytoskeleton |
|
TBCD and TBCE are also capable of acting in a reverse reaction in which they disrupt native heterodimers |