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FLASH GENE
Symbol NOP56 contributors: mct - updated : 27-08-2014
HGNC name nucleolar protein 5A (56kDa with KKE/D repeat)
HGNC id 15911
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast S.cerevisiae sik1p
homolog to Drosophila nop56
homolog to C.elegans K07C5.4
Homologene
FAMILY
  • NOP5/NOP56 family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in pre-mRNA processing
  • required for 60S ribosomal subunit biogenesis
  • NOP56 and NOP58 are required for ribosome biogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text ribosome biogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • FBL and and NOP56 directly interact (interaction, indispensable for the association of both proteins with the box C/D snoRNPs)
  • RUVBL2, RUVBL1 efficiently bridge interactions between the core box C/D proteins NOP56 or NOP58 and NHP2L1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCA36
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS