protein
| with HIP2 (Huntingtin interacting protein 2), a ubiquitin conjugating enzyme |
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interacting with TFCP2 and PHB2 (RNF2 and PHB2 modulate the TFCP2-mediated transcriptional pathway) |
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interaction between the C-terminal region of RNF2(C-RING1B) and the Pc cbox domain |
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target for phosphorylation by MAPK14 and ERK signaling pathways |
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expanded regulatory role for RING1, RNF2 proteins in the epigenetic regulation of gene expression |
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USP7 is a deubiquitinating enzyme that regulates the ubiquitination state of RNF2 (RNF2 interacts with USP7, which is mediated in part by its RING domain) |
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binds methylated chromatin through its association with another PcG protein called Polycomb (Pc) |
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UBE2D3 interacts with RNF2, in a manner fairly typical of E2-E3 interactions |
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by binding to the RING domain of RNF2, CDKN2A disrupts RNF2 homodimerization, providing a potential mechanism for its effect on RNF2 self-ubiquitination |
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CDKN2A specifically directs RNF2 into the E6-AP-mediated ubiquitination pathway by preventing its self-ubiquitination |
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CBX7 is necessary for recruitment of RNF2 to chromatin, whereas RYBP enhances the Polycomb repressive complex 1 enzymatic activity |
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RNF2 is an E3 ligase for TP53 degradation in selective cells |
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RNF2 functionally interacts with BCOR and is required to prevent colobomata |
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SNAI1 recruits RNF2 to mediate transcriptional repression and cell migration in pancreatic cancer cells |
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RNF2 potentiates AMBRA1 degradation with the help of WASH1 |
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OGT modifies and regulates an essential epigenetic tool, RNF2, which may contribute to embryonic stem cells (hESC) pluripotency maintenance and differentiation |
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RNF2 regulates distinct biologic processes in the genesis and progression of melanoma via different molecular mechanisms |
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RNF2 is an important upstream negative regulator of SIK1 and restoration of SIK1 levels induced by loss of RNF2 inhibited hepatocellular carcinoma (HCC)cell growth and promoted apoptosis |
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RYBP inhibits the polyubiquitination-mediated proteasomal degradation of RNF2 independently of its ubiquitin (Ub)-protein isopeptide ligase (E3) ligase activity |
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RYBP modulates stability and function of RNF2 through targeting UBE3A |