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FLASH GENE
Symbol WFDC5 contributors: mct - updated : 25-05-2011
HGNC name WAP four-disulfide core domain 5
HGNC id 20477
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal signal peptide
  • two WAP-type domains (Whey acidic proteins), WAP domains playing pivotal roles in the antimicrobial and/or antiprotease activities and their application in therapeutics are expected to have practical value
    • HOMOLOGY
    interspecies homolog to murine Wfdc5
    Homologene
    FAMILY WAP-type four-disulfide core (WFDC) domain family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be playing a role in host defence against invading micro-organisms or in the regulation of endogenous proteolytic enzymes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by NFIB (involved in the cooperative regulation of whey acidic protein (WFDC5) gene transcription along with the glucocorticoid receptor and STAT5
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS