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FLASH GENE
Symbol WFDC5 contributors: mct - updated : 25-05-2011
HGNC name WAP four-disulfide core domain 5
HGNC id 20477
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly Homo sapiens
 salivary gland   highly Homo sapiens
Reproductivemale systemtestis   
 male systemmale genital tractepididymis  
Respiratoryrespiratory tracttrachea  highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text pregnant uterus
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal signal peptide
  • two WAP-type domains (Whey acidic proteins), WAP domains playing pivotal roles in the antimicrobial and/or antiprotease activities and their application in therapeutics are expected to have practical value
    • HOMOLOGY
    interspecies homolog to murine Wfdc5
    Homologene
    FAMILY WAP-type four-disulfide core (WFDC) domain family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be playing a role in host defence against invading micro-organisms or in the regulation of endogenous proteolytic enzymes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by NFIB (involved in the cooperative regulation of whey acidic protein (WFDC5) gene transcription along with the glucocorticoid receptor and STAT5
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS