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FLASH GENE

Symbol

WFDC5

contributors: mct - updated : 25-05-2011

HGNC name	WAP four-disulfide core domain 5
HGNC id	20477

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_145652 4 - 1008 - 123 - 2006 16462094

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     highly Homo sapiens   salivary gland       highly Homo sapiens Reproductive male system testis         male system male genital tract epididymis     Respiratory respiratory tract trachea     highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	pregnant uterus

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal signal peptide
	two WAP-type domains (Whey acidic proteins), WAP domains playing pivotal roles in the antimicrobial and/or antiprotease activities and their application in therapeutics are expected to have practical value

HOMOLOGY

interspecies

homolog to murine Wfdc5

Homologene

FAMILY

WAP-type four-disulfide core (WFDC) domain family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION

may be playing a role in host defence against invading micro-organisms or in the regulation of endogenous proteolytic enzymes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

regulated by NFIB (involved in the cooperative regulation of whey acidic protein (WFDC5) gene transcription along with the glucocorticoid receptor and STAT5

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS