SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome
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| text
| present in the mitochondria, where its role in mitochondrial DNA (mtDNA) maintenance is independent of XRCC1  |
| basic FUNCTION
| can correct defective DNA strand-break repair |
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and sister chromatid exchange following treatment with ionizing radiation and alkylating agents |
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required for microhomology-mediated end joining of DNA double-strand breaks |
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critical biological role of LIG3 is to maintain mtDNA integrity and not XRCC1-dependent DNA repair |
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LIG3 function was central to mitochondrial DNA maintenance 0) |
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promotes alternative nonhomologous end-joining during chromosomal translocation formation |
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crucial for cell survival due to its catalytic function in mitochondria |
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restricted to higher eukaryotes and has been associated with base excision (BER) and single strand break repair (SSBR) |
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XRCC1, a LIG3-stabilizing cofactor, and LIG3 itself have been very widely assumed to provide major end-ligation functions in A-EJ (alternative end-joining) |
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remarkable ability for LIG3 to backup DSB repair by NHEJ in addition to its essential function in the mitochondria |
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LIG1 and LIG3 cooperate in alternative non-homologous end-joining |
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LIG1 is not absolutely required for cellular DNA replication and repair and either LIG3 or LIG4 can substitute for the role of LIG1 in joining Okazaki fragments |
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LIG3 isoforms were seven times more efficient than LIG1 at ligating nicked DNA under optimal conditions |
