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FLASH GENE

Symbol

STIM2

contributors: npt/mct/pgu - updated : 15-11-2017

HGNC name	stromal interaction molecule 2
HGNC id	19205

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function of STIM1 and STIM2 in T cells, and the consequent aberrations in T cell function, underlies the onset and progression of salivary gland autoimmunopathy in Sjögren syndrome

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice deficient for both endoplasmic reticulum calcium sensor Stim1 and Stim2 was immunized with T-cell dependent and independent antigens