Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BHLHE22 contributors: mct - updated : 30-10-2020
HGNC name basic helix-loop-helix family, member e22
HGNC id 11963
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Bhlhb5
homolog to zebrafish zgc64225
intraspecies homolog to NEUROD2
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • involved in regulation of spinal interneuron development
  • KLF9, BHLHE22, Hairless (Hr), are regulated specifically
    • by T3 in purified oligodendrocyte precursor cells (OPCs)and involved in oligodendrocyte differentiation and myelin regeneration
  • broad expression pattern of BHLHE22 throughout retinogenesis suggesting cell-autonomous as well as non-cell-autonomous role of BHLHE22 in the specification of amacrine and bipolar subtypes
  • role for BHLHE22 in the development of neurons that mediate sensory integration
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRDM88 is an obligate partner of BHLHE22, forming a repressor complex that directs neural circuit assembly in part through the precise regulation of CDH11
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for DURS1
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking Bhlhb5 showed a dramatically diminished number of neurons, including unipolar brush and cartwheel cell