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FLASH GENE
Symbol BHLHE22 contributors: mct - updated : 30-10-2020
HGNC name basic helix-loop-helix family, member e22
HGNC id 11963
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbraincerebellumcerebellar cortexhighly
Reproductivemale systemprostate  moderately
Respiratorylung    
Urinarykidney   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Bhlhb5
homolog to zebrafish zgc64225
intraspecies homolog to NEUROD2
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • involved in regulation of spinal interneuron development
  • KLF9, BHLHE22, Hairless (Hr), are regulated specifically
    • by T3 in purified oligodendrocyte precursor cells (OPCs)and involved in oligodendrocyte differentiation and myelin regeneration
  • broad expression pattern of BHLHE22 throughout retinogenesis suggesting cell-autonomous as well as non-cell-autonomous role of BHLHE22 in the specification of amacrine and bipolar subtypes
  • role for BHLHE22 in the development of neurons that mediate sensory integration
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRDM88 is an obligate partner of BHLHE22, forming a repressor complex that directs neural circuit assembly in part through the precise regulation of CDH11
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for DURS1
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking Bhlhb5 showed a dramatically diminished number of neurons, including unipolar brush and cartwheel cell