| basic FUNCTION
| involved in repairing covalent topo-isomerase 1-DNA complexes |
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remove glycolate from single-stranded DNA containing a 3'- phosphoglycolate, suggesting a role in repair of |
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free-radical mediated DNA double-strand breaks |
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required for repair of chromosomal single-strand breaks arising independently of DNA replication from abortive top1 activity or oxidative stress |
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playing a role in the repair of DNA damage mediated by topoisomerase II |
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required for neural homeostasis |
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critical for DNA chromosomal single-strand breaks repair in primary neural cells and required to prevent progressive cerebellar atrophy |
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hydrolyzes the phosphodiester bond between a tyrosyl moiety and a DNA 3prime-end |
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playing a role in repair of 3'-phosphoglycolate-terminated DNA double-strand breaks (Zhou 2009) |
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its optimal function requires its phosphorylation by ATM and/or (Das 2009) |
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required for efficient repair of oxidative damage in mitochondrial DNA, and is a novel mitochondrial enzyme  |
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role of TDP1 in protecting against oxidative DNA damage in mitochondria |
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involvement of TOP1, TDP1 , and single-strand break repair (SSBR) in modulating transcription-dependent CAG repeat contractions |
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TDP1 and TDP2 fulfil overlapping roles following TOP1-induced DNA damage, but not following TOP2A-induced DNA damage |
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role of cytoplasmic TDP1 is the repair of mitochondrial DNA lesions arising from oxidative stress |
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role of TDP1 and APTX in mitochondrial DNA repair |
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not only excises trapped topoisomerases I (Top1 in the nucleus and Top1mt in mitochondria), but also repairs oxidative damage-induced 3'-phosphoglycolates and alkylation damage-induced DNA breaks |
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catalyzes the repair of 3prime-DNA adducts, such as the 3prime-phosphotyrosyl linkage of DNA topoisomerase I to DNA |
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a role for TDP1 during the early stages of mammalian NHEJ (non-homologous end joining) |
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functional significance of PARP1 and TDP1 interaction in the process of DNA repair |
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DNA repair enzyme that removes irreversible protein-linked 3' DNA complexes, 3' phosphoglycolates, alkylation damage-induced DNA breaks, and 3' deoxyribose nucleosides |
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potential role of TDP1 in both canonical non-homologous end joining and alternative end joining, but not in the homologous recombination repair pathway |
