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FLASH GENE

Symbol

DCC

contributors: mct - updated : 22-06-2016

HGNC name	deleted in colorectal carcinoma
HGNC id	2701

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MMVC

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     homozygously deleted in colorectal cancer cell lines and other tumor types including stomach, pancreas, esophagus, prostate carcinomas tumoral     --low   by promoter hypermethylation in esophageal squamous cell carcinoma tumoral     --low   in more than 50p100 of colorectal tumours, as well as in many other neoplasms

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

unc5c haploinsufficiency results in diminished amphetamine-induced locomotion in male and female mice and this phenotype is identical to that produced by dcc haploinsufficiency and observed after adolescence