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FLASH GENE
Symbol DCC contributors: mct - updated : 22-06-2016
HGNC name deleted in colorectal carcinoma
HGNC id 2701
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four Ig-like C2-type domains
  • six fibronectin type III-like extracellular domains
    • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to murine Dcc (96.5pc)
    homolog to rattus Dcc (96.5pc)
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • DCC family
    • CATEGORY adhesion , tumor suppressor , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • spinal commissural axons
  • partially located to lipid rafts
    • basic FUNCTION
  • part of NTN1 receptor, inducing apoptosis in a caspase 9 dependent pathway by a mechanism independent of the intrinsic (mitochondria-dependent) apoptotic pathway, antagonized by NTN1
  • inducing attraction in axon guidance through its cytoplasmic tail
  • inducing apoptosis in the absence of its ligand
  • dependence receptor that may require lipid raft localization for cell death signaling
  • may function as a tumor suppressor gene in the esophagus
  • associating with protein synthesis machinery and regulating translation
  • its association with UNC5 proteins may trigger signaling for axon repulsion
  • DCC functions as a tumour suppressor via its ability to trigger tumour cell apoptosis
  • unction of DCC as a dependence receptor and a conditional tumour suppressor seems to represent an important safeguard mechanism, limiting tumour progression by engaging the apoptotic process
  • function of DCC as a context-dependent tumour suppressor that limits survival of disseminated tumour cells
  • NTN1/DCC/UNC5C chemotropism contributes to axonal confinement within the CNS
    • CELLULAR PROCESS cell life, cell death/apoptosis
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS nervous system
    text dependence receptor inducing apoptosis when unoccuped by ligand but inhibiting apoptosis in the presence of ligand
    PATHWAY
    metabolism
    signaling
    a component
  • forming a ROBO/DCC receptor complex, silencing netrin NTN1 attraction
  • forming a binding complex containing multiple translation components
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • caspase 9, caspase 3
  • NTN1/DCC pair may also regulate neuron survival during nervous system development
  • activating MAPK signaling, required for NTN1 mediated axon outgrowth and guidance
  • DCC could regulate cell adhesion and migration through its association with ERM-M (ezrin/radixin/moesin and merlin) proteins
  • interacting with SRC and FAK to mediate axon attraction
  • interacting with UNC5A, UNC5B, UNC5C and probably with UNC5D
  • ROBO1 interacts with the full-length DCC receptor
  • DCC promotes movement of MYO10 along basal actin filaments and enhances MYO10-mediated basal filopodium elongation
  • NTN1 binds to DCC and DSCAM mediating axon attraction, and UNC5 mediating axon repulsion
  • MAPK8 is important in the coordination of DCC and DSCAM in NTN1-mediated attractive signaling
  • DCC cooperates with DSCAM through regulating JNK activity in NTN1 signaling
  • combination of DSCAM with DCC or UNC5C plays an important role in NTN1-mediated axon attraction or repulsion
  • NTN1-UNC5C/DCC interaction is involved in controlling the interhemispherical projection in a subset of early born, deep layer callosal neurons
  • NTN1, a canonical guidance cue, induced the interaction of TUBB3 with the netrin receptor DCC
    • cell & other
  • potentially involed in cell-cell or cell-matrix interactions
    • REGULATION
    activated by cleavage (apoptosis defect) by caspase
    Other ubiquitinated, mediated by SIAH1 or SIAH2, leading to its subsequent proteasomal degradation
    ASSOCIATED DISORDERS
    corresponding disease(s) MMVC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    homozygously deleted in colorectal cancer cell lines and other tumor types including stomach, pancreas, esophagus, prostate carcinomas
    tumoral     --low  
    by promoter hypermethylation in esophageal squamous cell carcinoma
    tumoral     --low  
    in more than 50p100 of colorectal tumours, as well as in many other neoplasms
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • unc5c haploinsufficiency results in diminished amphetamine-induced locomotion in male and female mice and this phenotype is identical to that produced by dcc haploinsufficiency and observed after adolescence