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FLASH GENE
Symbol VEZF1 contributors: mct/npt/pgu - updated : 05-06-2016
HGNC name vascular endothelial zinc finger 1
HGNC id 12949
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six C2H2-type zinc finger motifs tandemly repeated
  • four potential N-glycosylation sites
  • VEZF1-specific binding sites are sufficient to mediate demethylation and protection of the APRT gene promoter from DNA methylation
    • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Vezf1
    homolog to Drosophila CG1832
    homolog to C.elegans C55B7.12
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • mediating TAX transactivation of IL-3
  • transcription factor that is expressed in endothelial cells and plays a requisite role in the regulation of angiogenesis
  • plays a widespread role in the control of DNA methylation
  • regulates genomic DNA methylation through its effects on expression of DNA methyltransferase DNMT3B
  • implicated in the development of the blood vascular and lymphatic system
  • early zinc finger transcription factor that is essential for normal vascular development and functions in a dose-dependent manner
  • nvolved in early differentiation processes of the vasculature by regulating cell differentiation, proliferation, and ECM distribution and deposition
  • plays multiple roles important for embryonic development
    • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • cellular defense response
  • activator
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • binding to the interleukin-3 promoter (to the CT/GC-rich regon) in cooperation with TAX
  • MT1A is a downstream target of VEZF1 in endothelial cells and is involved in the regulation of angiogenesis
  • interacts with the CGI promoter of the DHFR gene
  • VEZF1 interacts with MORF4L1/MRGBP, a protein that recognizes H3K36 trimethylation, consistent with the role of histone modifications at alternatively spliced sites
  • SETBP1 is a crucial target of TRIM29, and TRIM29 facilitated SETBP1 transcriptional activation via the VEZF1 transcription factor
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in Vezf1(-/-) mouse embryonic stem (mES) cells, widespread changes in gene-expression profiles, including decreased expression of the full-length active isoform of Dnmt3b methyltransferase and concomitant genome-wide reduction in DNA methylation