Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

DDB2

contributors: mct - updated : 04-12-2018

HGNC name	damage-specific DNA binding protein 2, 48kDa
HGNC id	2718

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

XPE

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         in xeroderma pigmentosum, type E

Susceptibility

to progressive supranuclear palsy (PSP)

Variant & Polymorphism SNP	increasing the risk of progressive supranuclear palsy (PSP)

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate may be a potential regimen for prostate cancer treatment, especially in androgen-refractory patients harboring high amount of AR who cannot be cured by androgen ablation

ANIMAL & CELL MODELS

	DDB2–/– mice are susceptible to UV-induced skin carcinogenesis
	mice genetically deficient in Ddb2 exhibited increased susceptibility to colon tumor development in a manner associated with higher abundance of the Wnt receptor-expressing cells and greater activation of the downstream Wnt pathway