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FLASH GENE

Symbol

DDB1

contributors: mct/pgu - updated : 19-05-2021

HGNC name	damage-specific DNA binding protein 1, 127kDa
HGNC id	2717

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HIDDA

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   prevents hepatocytes to replicate DNA, induces compensatory proliferation of DDB1-expressing hepatocytes, and eventually leads to development of hepatocellular carcinoma constitutional         DDB1 silencing activates TP53 pathway and leads to significant effects on cell cycle progression and rapid apoptosis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS